Resolution in Periodontal Inflammation- A Review

When inflammation is initiated, goal of host response is to quickly return to homeostasis through rapid elimination of invading leucocytes. Resolution of inflammation is an active process. Cells and events are stimulated to respond, which is quite different from blocking pro-inflammatory pathways. The Harward school medical team identified a new class of fats, resolvins, which control inflammation by stopping the migration of inflammatory cells. Eicosapentaenoic acid acts as a precursor for resolvins which are produced by omega-3 fatty acids. Discovery of resolvins and their use in an inflammatory disease model have provided insight into the determinants of susceptibility of periodontics. Prevents repair, helps regeneration.....